The C-terminal bipartite ubiquitin-binding domain (UBD) of ABIN1, also named UBD in ABIN proteins and NEMO (UBAN), is homologous to NEMO ubiquitin binding domain (NUB) which binds ubiquitin chains and potentiates many functions of ABIN1, including inhibiting NF-κB signaling [7–11], preventing inflammatory and autoimmune diseases [3, 12–14] and restricting programmed cell death [2]. This evidence concerns the gene TNIP1 and autoimmune disease.