Consistent with the results obtained in Jurkat T cells, knockdown of ABIN1 increases HIV-1 replication in CD4+ T lymphocytes to twofold to threefold at day 1, sixfold to eightfold at day 3, and about threefold at day 5 post infection (Fig. 1b, upper panel). The gene discussed is TNIP1; the disease is infection.