The main observations of this study were that childhood cancer survivors in the highest tertile of the leptin/adiponectin ratio, BFP, and HOMA index presented with lower levels of adiponectin per/kg/fat, a greater waist circumference, high concentrations of leptin and triglycerides, a higher systolic blood pressure and lower HDL-C concentrations. Here, LEP is linked to childhood malignant neoplasm.