Notably, in GFAP/IKK2-CA animals we found a pronounced downregulation of EAAT1 and EAAT2 already at 10 weeks (Fig. 8a) correlating with transgene expression (Fig. 2j) and in line with a potential pathogenic role in ataxia and Purkinje cell loss. This evidence concerns the gene IKBKB and cerebellar ataxia.