For the majority of genes that showed an initial increase, all transcripts in HepG2 infected cells showed reduced levels by day 3 post infection (below the level of mock infected cells), while for HEK293T/17 cells, some transcripts still showed an increase over mock by day 3 (PPARα, AOX and SCD1), while others were either not different from mock at day 3 (ACC1, CPT1, MCAD) or significantly reduced as compared to mock infected cells (FASN, ATGL, SREBP1c). The gene discussed is ACACA; the disease is infection.