Importantly, ectopic expression of phospho-resistant ALDH1A1 not only fully inhibits ALDH1A1-mediated oncogenic pathways, but even reduces the basal levels of Snail, Slug, N-cadherin, vimentin, MMP-2, and CD44 in BxPC3 cells, highlighting a vital role of AURKA in ALDH1A1-mediated signaling in cancer cells. This evidence concerns the gene MMP2 and cancer.