CD40LG and infection: PBMC (week 12) gene networks identified included the activation of T cell development, differentiation of TH1 cells, maturation and memory of T lymphocytes by nodes of interaction for the genes CD40LG, LCK, LEF1, IFNAA1/A13, IL-22, TNFSRSF4, LTB, CCL3 and CD27. A distinct phenotype was observed in PBMC (week 20) after infection with S. mansoni—most likely due to the immune recall response and clearance of the pathogen.