A significant positive correlation was observed between P. falciparum infection densities and HRP2 concentration (S3 Fig), as has been reported previously [26, 27], but with variation regardless of whether parasitemia was determined through light microscopy (R2 = 0.285, p<0.001) or nucleic acid-based qPCR methods (R2 = 0.091 and 0.193, p<0.001). Here, HDGFL2 is linked to parasitic infectious disease.