Notably, p62, which is a bona fide target of autophagosomal degradation declined at 1h to accumulate at 2h and 4h post infection, indicating that the autophagic flux was initially increased and subsequently impaired indicating a short and transient phase of autophagy in S. Typhimurium-infected cells (Fig 5B and 5C). This evidence concerns the gene SQSTM1 and infection.