In agreement with the phosphorylation of 70S6K in the majority of the AR-DLBCL cases, the phosphorylation of PTEN, a tumor suppressor and the major negative regulator of the PI3K/AKT/mTOR pathway, was observed in 68–77% of AR-DLBCLs, substantiating our findings that the negative suppression of mTOR in AR-DLBCL was relieved by PTEN. This evidence concerns the gene MTOR and diffuse large B-cell lymphoma.