ANGPT1 and hypertensive disorder: With regards to the renal effects of Ang 1–7, it has been reported that Ang 1–7 administration had adverse renal effects in a model of unilateral uretaral obstruction (UUO) in the mouse [17] and uninephrectomised sheep [19], was not renoprotective in a rat model of focal segmental glomerulosclerosis [18], had no effect on renal function or hypertension in the Goldblatt model of 2-kidney, 1-clip hypertension (2K1C) [37], and increased mesangial area in a mouse model of 5/6 STNx [38].