Although epidemic cholera is caused by cholera toxin-positive V. cholerae, strains without cholera toxin can cause a diarrheal disease through other possible virulence factors, including the heat-stable toxin (NAG-ST) [33], hemolysin (Hly), type III secretion system (T3SS) [34, 35], cholix toxin (Chx) [36, 37], mannose sensitive hemagglutination (MshA) and repeat in toxin (RtxA). This evidence concerns the gene KRCC1 and vibrio infectious disease.