We previously reported the characterization of a zebrafish optic pathway tumor model in which transgenic Tg(flk1:RFP)is18/+ adults develop nonmalignant retinal tumors at ∼80% penetrance.37 The molecular basis for tumor induction is not known; however, our analyses showed that the retinal tumors may originate, in part, from Müller glia-derived progenitors, and activated signaling pathways in the tumor transcriptome are similar to injury induced regeneration pathways driving Müller glia reprogramming and progenitor proliferation. Here, KDR is linked to retina neoplasm.