IPA analysis showed increased expression or activation of many components in the VEGF regulatory pathway that promotes tumor cell invasion (Fig. 4d and Supplementary Table S5), including multiple growth factors (tgfβ, hbegf), cytokines (endothelin-1, cxcl12), matrix metalloproteases, and peptidases (mmp2, mmp9, plau), and enzymes involved in prostaglandin synthesis (cox2, ptgs2). This evidence concerns the gene PLAU and neoplasm.