The glomerular Ccl2 and Adgre1 expression and the M1/M2 macrophage marker ratio were decreased in Rosa-CTGF cKO and Pdgfra-CTGF cKO mice, indicating that CTGF expression particularly in mesangial cells is critical to induction of inflammation in anti-GBM nephritis. This evidence concerns the gene CCL2 and nephritis.