Thirdly, we also established PDGFRα promoter-driven CTGF conditional KO (Pdgfra-CTGF cKO) mice, which predominantly lack CTGF expression in mesangial cells of the glomeruli, to investigate the cell type-specific contribution of CTGF in anti-GBM nephritis model. The gene discussed is CCN2; the disease is glioblastoma.