After gene ontology analysis, we confirmed a statistically significant enrichment for genes playing a role in renal system development (66/265, such as HOX genes, LHX1, and LEF1) and in particular, a significant presence of genes involved in metanephros development (35/91, such as EYA1, FOXD1, and FBN1), mesenchyme development (9/19, such as FOXC2, SIX2, and MEOX1), and MM development (7/15, such as OSR1, SIX1, and WT1), confirming the MM origin of the isolated NPs (Fig. 3C, 3D). The gene discussed is SIX2; the disease is Miyoshi myopathy.