We show here that MLD patient‐specific hiPSCs can be safely and efficiently engineered to express supraphysiological levels of the ARSA enzyme, differentiate into hfNSC‐like neural stem cells, and may serve as autologous source for stable ARSA supply and amelioration of sulfatide storage in MLD‐affected brains. Here, ARSA is linked to metachromatic leukodystrophy.