As shown in Figure 4(a), MCF-7 cells transfected with miR-221 mimics could significantly increase the level of miR-221, and upregulation of miR-221 level significantly decreased Bim mRNA and protein levels (Figures 4(b) and 4(c)), which is consistent with the previous study that miR-221 can target Bim in breast cancer [17]. This evidence concerns the gene BCL2L11 and breast cancer.