HAMP and granular corneal dystrophy type II: Indeed, hepcidin regulation is finely tuned by opposing stimuli: on one hand by proinflammatory molecules which enhance its production and lead to ACD during inflammatory/infectious conditions on the other hand, by the EPO-ERFE axis, which, according to recent data, appears to keep hepcidin suppressed in order to recover from a hypoxic state and to restore erythropoiesis.