EZH2-specific inhibition is an active area of researcher, with several human phase 1 and 2 trials now underway, such as an ongoing phase II, multicenter study of the EZH2 inhibitor tazemetostat in adult subjects with INI1-negative tumors or relapsed/refractory SS (https://clinicaltrials.gov/ct2/show/NCT02601950). This evidence concerns the gene EZH2 and synovial sarcoma.