The increased insulin concentration also could explain why circulating glucose was lower in OVE + SM cows [25] compared with CON, i.e. overfeeding alone does not affect peripheral insulin resistance [9], and the increased insulin concentration was not followed by changes in GH or IGF1, hence, the improved milk production with OVE + SM also might have resulted from an increase in glucose availability directly channeled to peripheral tissues and the mammary gland. The gene discussed is INS; the disease is Insulin resistance.