A tumor suppressor gene most commonly deleted or mutated in mesotheliomas (∼60% of cases) is BRCA1 associated protein-1 (BAP1), a C-terminal family of deubiquitinating enzymes (DUBs) linked to DNA damage repair regulation [36, 63, 67, 83, 143-145]. The gene discussed is BAP1; the disease is mesothelioma.