Our analysis also demonstrated up-regulated transcripts of ALDOA and hub genes could mostly distinguish tumors from controls not only in NSCLC, but also in other tumors, namely cervical cancer, breast cancer and hepatocellular carcinoma, suggesting that transcription of ALDOA might contribute to increased cell cycle-related cell proliferation, and be an important and probably universal step in carcinogenesis. Here, ALDOA is linked to non-small cell lung carcinoma.