PPARGC1A and obesity due to melanocortin 4 receptor deficiency: Interestingly, recent studies show that epigenetics may play a role in determining mRNA splicing [26] in addition to its role in determining transcription initiation and −1 nucleosome positioning may play a role in determining FL-Pgc-1α and total NT-Pgc-1α expression in skeletal muscle in relation to cardiovascular disease during overweight and obesity [15].