To directly assess this, as well as to address a possible adjunct role of stroma-derived IL-23, the colitis-associated colon cancer model was also tested in WT mice stably reconstituted with IL-23p19−/− hematopoiesis and in IL-23p19−/− mice reconstituted with WT hematopoietic cells. The gene discussed is IL23A; the disease is colonic neoplasm.