The intensity of phosphorylated Akt was assessed using a semiquantitative 3‐point scale (0‐3+) and the proportion of cells staining called by a dedicated pediatric pathologist (HC); 15 (71%) of 21 patients demonstrated at least 2+ staining in 50% or more of the tumor cells (see Fig. 2A–C), and it was present in blastemal (panel 2A), stromal (panel 2B), and epithelial elements (panel 2C). The gene discussed is AKT1; the disease is neoplasm.