We were unable to find any correlation between BNP, which identified patients with cardiac-related dyspnoea with a sensitivity of 99% and a specificity of 41% [26], and 3BOHB concentration; however, our findings support an increased circulating 3BOHB concentration in T2DM patients independently of the presence of overt heart failure [15]. This evidence concerns the gene NPPB and type 2 diabetes mellitus.