Shah et al. demonstrated that using lower cutoffs for hs-cTn I (5 ng/L) identifies low-risk patients for the composite outcome of index myocardial infarction, and myocardial infarction or cardiac death at 30 days with an NPV of 99.6% (95% CI 99.3–99.8%) [27]. The gene discussed is TNNI3; the disease is myocardial infarction.