By using OSE-specific monoclonal antibodies (particularly T15/E06 IgM), recognizing oxidatively modified but not native phospholipids, Witztum, Tsimikas and colleagues found correlations between plasma levels of oxidized phospholipids and plasma Lp(a), apo(a) size polymorphism, CVD and progression of aortic valve stenosis [1, 26, 27]. This evidence concerns the gene LPA and aortic valve stenosis.