Furthermore, genetic deficiency of secreted IgM (sIgM-/-) in mice dramatically accelerates atherosclerosis on the LDL receptor deficient (Ldlr-/-), atherosclerosis-susceptible mouse background, parallel with increased plasma IgE levels and perivascular accumulation of mast cells and neutrophils within the plaques [33]. The gene discussed is CD40LG; the disease is atherosclerosis.