Since the modulation of the expression of Tspan8 does not affect the in vitro proliferation and motility of melanoma cells [23], it may be postulated that Tspan8 specifically modulates cell-matrix adhesion and invasion phenotypes in cutaneous melanoma, whereas it regulates proliferation and migration in other cancers, independently and dependently of FAK, respectively. The gene discussed is PTK2; the disease is cutaneous melanoma.