BIN1 and myotonic dystrophy type 1: Moreover, expression of hU7-(CAG)15 antisense transcripts reduced the number of nuclear CUGexp-RNA aggregates in DM1-cl5 muscle cells (Fig. 5C) and partially corrected DM1-associated splicing changes for BIN1 exon 11, DMD exon 78 and LDB3 exon 11 (Fig. 5D).