Furthermore, RT-PCR analysis showed that the splicing pattern of BIN1 exon 11, DMD exon 78 or LDB3 exon 11 pre-mRNAs was significantly deregulated in differentiated DM1-cl5 or DM1-cl6 muscle cells compared with Ctrl-cl4 or Ctrl-cl48 and DM2-cl26 or DM2-cl33 muscle cells (Fig. 2D). This evidence concerns the gene DMD and myotonic dystrophy type 1.