Interestingly, DM1 transdifferentiated myotubes displayed splicing changes of many transcripts including ATP2A1, BIN1, INSR, LDB3, MBNL1 and TNNT2 (Fig. 3C,D) that are also misregulated in skeletal muscles of DM1 patients (Nakamori et al., 2013). This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.