In accordance with previous results obtained in DM1 myoblasts (Mulders et al., 2009; Pantic et al., 2016), 2′OMe-PT-(CAG)7 ASO treatment of DM1-cl5 myoblasts significantly decreased the number of nuclei with nuclear RNA aggregates (Fig. 4A), which was associated with a redistribution of sequestered MBNL1 proteins into the nucleoplasm (Fig. 4B). This evidence concerns the gene KIR3DL2 and myotonic dystrophy type 1.