INSR and myotonic dystrophy type 1: Interestingly, DM1 transdifferentiated myotubes displayed splicing changes of many transcripts including ATP2A1, BIN1, INSR, LDB3, MBNL1 and TNNT2 (Fig. 3C,D) that are also misregulated in skeletal muscles of DM1 patients (Nakamori et al., 2013).