DMPK and myotonic dystrophy type 1: We found that CAG antisense treatments that target the expanded CUG tract such as hU7-(CAG)15 or ASO-(CAG)7, decrease the number of nuclear CUGexp-RNA aggregates, which has previously been shown to correlate reduced levels of CUGexp-DMPK mRNA, and correct splicing defects in our immortalized DM1 muscle cells.