Interestingly, the strongly differentially regulated ITRs were significantly enriched for the Neurotrophin signalling pathway (BDNF, NGF and Trk receptors etc., see 'MYCN overexpression antagonises the normal transcriptional response to RA treatment' section above; KEGG p = 5.739E-10; Additional file 1: Figure S4b), which is strongly associated with neuronal differentiation and neuroblastoma outcome. The gene discussed is BDNF; the disease is neuroblastoma.