This paper also showed significantly lower expression of negative regulators such as A20-binding inhibitor of NFκB activation 3 (ABIN3), activating transcription factor 3 (ATF3), IL-1 receptor-associated kinase M (IRAK-M), and suppressor of cytokines signalling 3 (SOCS3) in FLS in RA compared to macrophages. This evidence concerns the gene SOCS3 and rheumatoid arthritis.