Although there were no statistical differences of the proportions of IFN-γ+ T cell positive individuals between seasonal influenza H1N1 (91%, 57/63) and H1N1pdm (86%, 54/63) among the total subjects (Fisher Exact Test, p = 0.6), the overall magnitudes of IFN-γ+ SFC against seasonal influenza (mean ± SE = 47 ± 8) were significantly higher than those against H1N1pdm (mean ± SE = 34 ± 5) (Paired T-Test, p = 0.02). The gene discussed is IFNG; the disease is influenza.