One other lysosomal enzyme relevant to tumor progression, among the multiple hydrolytic enzymes present in lysosomes, is the unique enzyme heparanase; it should be noted that the final stage in the activation of heparanase occurs in the lysosome via proteolytic cleavage of a linker region encompassing Ser110–Gln157 mediated by cathepsin L [48], hence liberating an N-terminal 8-kDa subunit as well as a C-terminal 50-kDa subunit, which remain associated as a noncovalent heterodimer in the mature active heparanase [49]. Here, HPSE is linked to neoplasm.