Both cytokines participate in apoptotic processes; TRAIL is a major component of the extrinsic apoptotic pathway, which induces apoptosis in cancer cells, albeit with disappointing results in clinical trials [40], while VEGI/TLA1, the only known ligand of Death Receptor 3, can inhibit the proliferation of breast carcinoma and increase breast cancer patient survival [22]. The gene discussed is TNFRSF25; the disease is cancer.