Jing Ke et al. determined that HOTAIR promotes the development of glioma by inhibiting miR-326 and further promoting increased expression of fibroblast growth factor 1 (FGF1) [73], which has a significant oncogenic function in tumorigenesis through activation of the MEK1/2 and PT3K/AKT pathways [75]. Here, HOTAIR is linked to central nervous system cancer.