MALAT1 and neoplasm: Moreover, inhibition of ERK signaling (U0126) imitates MALAT1 overexpression-induced levels of phosphorylated ERK1/2 and MMP2, indicating that the tumor-suppressive function of MALAT1 is mediated by attenuating ERK/MAPK-mediated cell growth and MMP2/9-mediated invasiveness [55].