In this study, we found that Dvl2 alone inhibited cIAP2 but not cIAP1 in RA-FLSs, though both were significantly inhibited upon TNF-α stimulation; the reason for this difference may be because cIAP1 and cIAP2 vary with regard to expression and function [40]. The gene discussed is DVL2; the disease is rheumatoid arthritis.