CXCL8 and phyllodes tumor: When we compared CM of stromal cells from fibroadenoma and phyllodes tumors, a number of proangiogenic and proinflammatory human cytokines showed significantly higher concentration in CM from phyllodes stromal cells than fibroadenoma cells, including interleukin-6 (IL-6), IL-8, and vascular endothelial growth factor (VEGF), [IL-6 (p = 0.044), IL-8 (p = 0.012), and VEGF (p = 0.05)] (Figure 6A and 6B).