CTSS and neoplasm: It is known that tumor and inflammatory cells secrete proteolytic enzymes, proteases such as serine (thrombin-like and trypsin-like), metallo- (Matrix metalloproteases), and cysteine proteases (cathepsins-cysteine proteases) that can activate platelets by inducing alterations in the paracrine signaling manner and formation of the fibrin network with consequent support for thrombin generation [24–27].