CDH1 and benign neoplasm: Consistent with the fact that the estrogen (E2) and progesterone (P4) pathways are overstimulated in these benign tumors, we observed that phyllodes stromal cells supplemented with PRP and treated with the E2+P4 combination (100 nmoles/L) induced EMT reversion with the expression of E-cadherin by stromal phyllodes cells (Figure 4B).