CD40L stimulation induced the expression of all markers CD80, CD83, HLA-DR and CD86 in iDC in contrast to stimulation with non-transfected A549 exhibiting again higher maturational plasticity than DC pulsed with HHP-killed tumor cells and poly(I:C).However, only DC pulsed with HHP-killed tumor cells and poly(I:C) were able to increase IL-12p70 production after CD40L stimulation (Fig 2B). The gene discussed is CD40LG; the disease is neoplasm.