Moreover, comparing the relative expression levels of these two isoforms both in normal and cancer tissues with respect to the ones of the one representative member of the miR-200b/200c/429 cluster (i.e. miR-200b), we found a drastic drop, in the pathological condition, in the relative concentration of the PVT1 isoform hosting the binding site for the miR-200b. This evidence concerns the gene PVT1 and cancer.