In RAGE gene, the commonest T-T-G-G haplotype (rs1800625-rs1800624-rs2070600-rs184003, similarly hereinafter) was frequently seen in controls compared with patients, and relative to this haplotype, T-T-A-G (OR; 95% CI; P: 1.75; 1.02-3.03; 0.045) and T-T-A-T (OR; 95% CI; P: 1.95; 1.01-3.76; 0.048) haplotypes were associated with a marginally increased risk of hepatocellular carcinoma after adjusting for confounders mentioned above, with the study power of 28.0% and 71.9%, respectively. The gene discussed is AGER; the disease is hepatocellular carcinoma.