HMGB1 and hepatocellular carcinoma: In HMGB1 gene, the frequency of T-C-T haplotype (rs1045411-rs2249825-rs1415125, similarly hereinafter) was significantly higher in patients than in controls (12.59% vs. 5.56%, P = 0.003) with the study power reaching 99.9%, and this haplotype was associated with a 2.47-fold (95% CI: 1.41-4.34; P = 0.002) increased risk of hepatocellular carcinoma after adjusting for BMI, smoking and drinking when compared with the commonest haplotype C-C-T.