The mutant alleles of two polymorphisms, rs1045411 in HMGB1 gene and rs2070600 in RAGE gene, had significantly higher frequencies in hepatocellular carcinoma patients than in controls (both P < 0.001), and this significance was attained even after the Bonferroni correction (P < 0.05/7). Here, AGER is linked to hepatocellular carcinoma.