EGLN3 and hereditary pheochromocytoma-paraganglioma: It was demonstrated in the pheochromocytoma-derived cell line PC12 that succinate accumulation induced cell growth not by its action on HIF1 but rather through inhibiting PHD3-dependent apoptosis, which led to the survival of embryonic neurons and the formation of paragangliomas/pheochromocytomas [207].