In accordance with this model, several studies have confirmed the role of germline mutations in the SDHAF1 [64, 72] and SDHAF2 genes [31, 59, 64, 65, 73–75] in the formation of head and neck paragangliomas/pheochromocytomas. The gene discussed is SDHAF2; the disease is hereditary pheochromocytoma-paraganglioma.