Five canonical pathways were inhibited, as determined through an evaluation of the z-score: dopamine-DARPP32 feedback in cAMP signaling (z-score = -2.24), CREB signaling in neurons (z-score = -2.24), cardiac hypertrophy signaling (z-score = -2.24), neuropathic pain signaling in dorsal horn neurons (z-score = -2.00) and synaptic long term potentiation (z-score = -2.00). This evidence concerns the gene CREB1 and cardiac hypertrophy.