In this study, we found that the expression of miR-124-3p was significantly decreased in AD cell model; the transfection of miR-124-3p mimics attenuated cell apoptosis and inhibited abnormal hyperphosphorylation of Tau protein by regulating Caveolin-1-PI3K/Akt/GSK3β pathway. The gene discussed is MAPT; the disease is Alzheimer disease.