We observed that the expression levels of both vascular endothelial growth factor receptor 2 (VEGFR 2), an important receptor for arterial differentiation of ECs, and alpha smooth muscle actin (aSMA), a smooth muscle cell marker, were elevated, but CD36 expression levels were reduced in certain tumor vessels (Figure 3A and 3B) although similar levels of CD36 and VEGFR2 were present in other tumor vessels in the DIO mice (Supplementary Figure 4). This evidence concerns the gene CD36 and neoplasm.