In vitro studies revealed that IFN-λ can upregulate cellular anti-HIV-1 factors through JAK-STAT signaling pathway and significantly inhibited HIV-1 infection [1, 12]; TLR-3 activated by Poly I:C can induce multiple anti-HIV-1 factors and inhibit HIV-1 infection of macrophages [22]. Here, SOAT1 is linked to HIV-1 infection.