PAK1 and posterior cortical atrophy: Based on the article about rapamycin and MYH1485 effects on cells [31–33], and we previously reported that different concentrations of inhibitor rapamycin remarkably inhibited PC-3 cell proliferation after 48 h (P < 0.05), inhibitory action did not change significantly from 5–100 nM [34], then we used rapamycin and MHY1485 to investigate the molecular mechanisms of PAK1 impact on PCa cells.