Anna Goc, et al. [18] have indicated that PAK1 expression in PC-3, C4-2 and VCaP was higher than LNCaP, and PAK1 expression was elevated significantly in PCa and metastatic lymph node and lung tissues, the study reported that PAK1 knockdown impaired PCa growth via increased expression of TGF-β and reduced secretion of MMP9, and then Ahmad Al-Azayzih, et al. [19] have researched DU145 and PC-3 and demonstrated that TGF-β1 induces apoptosis and EMT in the cells via activation of P38-MAPK and Rac1/Pak1 respectively. Here, MMP9 is linked to posterior cortical atrophy.