Vineeta Khare [22] have demonstrated that PAK1 expression is regulated by MEK, PI3K, and mTOR in normal diploid colon epithelial cells (HCEC-1CT) and PAK1 and beta-catenin expression correlated and inhibition of PAK1 and addition of 5-ASA elicited similar molecular affects by reducing ERK and AKT activation in colorectal cancer cell lines. Here, AKT1 is linked to colorectal cancer.