Shuchen Gu et al [40] found inhibition of mTOR blocked p70S6K and PAK1 phosphorylation and actin remodeling and demonstrated a mAR-governed pathway involving FAK/PI-3K and mTOR/p70S6K/PAK1-cascade that regulates early actin reorganization in colon cancer cells. The gene discussed is PTK2; the disease is malignant colon neoplasm.