According to immunohistochemistry results, higher positive expression of PAK1, p-PAK1, Ki-67, P504s and P53 was shown in PCa, both P63 and CK5/6 expression was negative in PCa, and higher positive expression of 34βE12, P63 and CK5/6 was in BPH, but the difference of mTOR, p-mTOR, PSA, PAP, AR and CK expression was not statistically significant between PCa and BPH. This evidence concerns the gene PAK1 and benign prostatic hyperplasia.