PAK1 and posterior cortical atrophy: Knockdown of PAK1 decreased DU145 PCa xenograft growth in nude mice by compared with the negative control, Western blot analysis suggested that PAK1, p-PAK1, Rac1 and p-mTOR expression was decreased in shRNA group than the NC and Blank, and mTOR expression tended to be decreased, indicating that PAK1 may promote the progression.