Our present study has shown that CAFs induced the phosphorylation of JAK2 and STAT3 of gastric cancer cells via the secretion of IL-6, and inhibiting JAK2-STAT3 pathway activation with AG490 significantly impaired cell migration and EMT, as well as peritoneal dissemination and metastasis in vivo induced by CAFs. The gene discussed is IL6; the disease is gastric cancer.