CAFs-derived IL-6 enhances the migration and EMT of gastric cancer cells by the activation of JAK2/STAT3 pathway in gastric cancer cells, while deprivation of IL-6 using a neutralizing antibody or inhibition of JAK2/STAT3 pathway with specific inhibitor AG490 markedly reduces these phenotypes in gastric cancer cells induced by CAFs. The gene discussed is STAT3; the disease is gastric cancer.