In order to test the target genes of miR-375 in CRC and the related signal pathways, we searched the databases miRTarBase, PicTar, TargetScan, miRecord and miRanda, and found that jak2, usp1, map3k8, timm8a, yap1, pdk1, atg7 are predicted to be the target genes of miR-375. The gene discussed is MAP3K8; the disease is colorectal carcinoma.