CCL2 and Insulin resistance: It has been demonstrated that interstitial macrophage infiltrates are common in DN [3] and in patients and animals, the pro-inflammatory chemokine C-C motif-ligand 2 (CCL2), also called monocyte-chemotactic protein 1 (MCP-1), is implicated in the development of insulin resistance [4], as well as macrophage infiltration [3].