Since membrane type 1 matrix metalloproteinase (MT1-MMP) is the primary enzyme used by stromal and cancer cells to degrade and migrate through fibrillar collagen29, 30 and the invasive epithelial phenotype involved cells moving outward through the surrounding collagen matrix, we next investigated whether MT1-MMP contributes to epithelial invasion in this system. The gene discussed is MMP14; the disease is cancer.